Manchester United will be hoping that captain Wayne Rooney is fit for selection ahead of their eagerly anticipated crunch clash with Arsenal in the Premier League at Old Trafford on Saturday.
The United skipper withdrew from the England squad following the 3-0 victory over Scotland last week with a minor knee problem, resulting in his absence from the 2-2 draw with Spain at Wembley on Tuesday.
Rooney will be desperate for the opportunity to continue to build on his impressive record against Arsenal, having netted 14 goals against them in all competitions, including that wonder strike when he burst onto the scene for Everton as a 16-year-old in October 2002 and a hat-trick for the Red Devils in the 8-2 rout of August 2011.
Jose Mourinho will also assess the fitness of Luke Shaw and Marouane Fellaini as he looks to maintain his unbeaten record against the Gunners in the Premier League - winning five and drawing six of his 11 previous encounters.
United, who currently sit sixth in the table, are seeking to close the gap on Arsenal and the top four to two points, but the Gunners arrive at Old Trafford protecting a run of 16 matches without tasting defeat in all competitions.
Arsene Wenger is waiting on the fitness of talisman Alexis Sanchez, who picked up a hamstring strain whilst on international duty with Chile, as he aims for just a second win in 11 meetings between the two sides.
However, right-back Hector Bellerin will definitely miss out on the mouth-watering showdown after being ruled out for four weeks with a knock.
He joins fellow Spaniard Santi Cazorla on the sidelines, as the latter continues his recovery from a foot injury.
The match at Old Trafford kicks off at 12.30pm GMT on Saturday, with a lot more than just bragging rights at stake for both sides in the Premier League.