Cerro Porteno could put one foot in the next round of the Copa Libertadores with a win at Deportivo Tachina tonight.
Cerro Porteno are second in Group Five at the halfway stage of this competition, and a win would see them open up a six-point lead over their hosts and, depending on the outcome of another match, third-placed Santos.
Deportivo Tachira, meanwhile, are desperately in need of a victory if they want to progress from the group stage.
These two teams drew 1-1 when they met earlier in the group stage.
Watch Deportivo Tachira v Cerro Porteno live at 365, kicking off at 23.30 GMT.